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SSO-CIC Symposium - SPEAKERS

Alberto Mantovani, MD, is Professor of Pathology at the Humanitas University in Milan, and Scientific Director of the Istituto Clinico Humanitas.  His attention has been focused on molecular mechanisms of innate immunity and inflammation. He has contributed to the advancement of knowledge in the field of Immunology formulating new paradigms and identifying new molecules and functions.

 

For his research activity he has received several national and international awards, such as the Triennial OECI Award from the Organization of the European Cancer Institutes,  the Robert Koch Award for his contribution to tumor immunology and immunotherapy, the American-Italian Cancer Foundation (AICF) Prize for Excellence in Medicine and, most recent, the American Association for Cancer Research International Pezcoller Award for Extraordinary Achievement in Cancer Research. The broad impact of his contributions is testified by citations.  As of November 2019 he has over 115,900 (Scopus), 108,900 (Web of Science) or 166,900 (Google Scholar) citations and an H-index of 163 (Scopus), 161 (Web of Science) or 187 (Google Scholar).

Humanitas University in Milan

Alberto MANTOVANI

Professor Jeffrey W. Pollard is Director of the Medical Research Council Centre for Reproductive Health and Professor of Resilience Biology at the University of Edinburgh. He is a Wellcome Trust Senior Investigator. Professor Pollard received his PhD at Imperial Cancer Research Fund (now CRUK) in London, UK, followed by a post-doc at the Ontario Cancer Institute in Toronto before taking a Lectureship at King’s College University of London.  Thereafter he was at the Albert Einstein College of Medicine in New York for over 24 years finally as the Louis Goldstein Swann Chair in Women’s Health, Deputy Director of the Cancer Center and Director of the NICHD funded-Center for the Study of Reproductive Biology and Women’s Health. In 2013 he moved to the University of Edinburgh.

 

His research was the first to show that macrophages promote tumour progression to malignancy and to enhance metastasis.  He has shown these activities are due to the enhancement of the angiogenic switch, promotion of tumour cell invasion and intravasation as well as at the metastatic site enhancement of tumour cell extravasation, survival and persistent growth. He has identified many reciprocal signalling pathways between tumour cells and macrophages including the mechanism of monocyte recruitment to the metastatic site via the chemokines CCL2 and CCL3 as well as roles for VEGFR1 and CSF1R signalling in macrophages. In addition, he has defined human tumor associated macrophages in breast and endometrial cancer and discovered novel signalling pathways that are prognostic for poor survival.  His work also pioneered the understanding of the roles for macrophages in regulating development, for example in branching morphogenesis, brain development and stem cell maintenance. In addition, he has demonstrated important roles of macrophages in tissue repair.  For his studies he was elected as a Fellow of the American Association for the Advancement of Sciences (AAAS) in 2011, Fellow of the Royal Society of Edinburgh in 2015 and Fellow of the Academy of Medical Sciences in 2016. He has received several awards most notably the American Cancer Society “Medal of Honor for Basic Science Research” for his studies in tumour immunology.

Medical Research Council Centre

Jeffrey W. POLLARD